The course focuses on fundamental principles of organogenesis in the nervous system and integrates information from a variety of model systems, relating them to human nervous system development trajectory, including disorders of development. It offers expanded coverage of topics such as neuronal determination, axonal navigation and targeting, neuron survival and death, synapse formation and developmental plasticity. Environmental exposures, epigenetics, gene expression, cell migration and stem cells, sleep and learning/memory, socioeconomic status and development of prefrontal cortex function are considered.